ASTM International - ASTM D6259-15(2019)

Standard Practice for Determination of a Pooled Limit of Quantitation for a Test Method

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Organization: ASTM International
Publication Date: 1 May 2019
Status: active
Page Count: 4
ICS Code (Test conditions and procedures in general): 19.020
significance And Use:

5.1 Background-In a single laboratory, the limit of quantitation, LOQ, equal to ten times the standard deviation obtained under repeatability conditions extrapolated to zero concentration... View More

scope:

1.1 This practice covers the use of standard regression techniques and data from an interlaboratory study to determine a lower quantitative limit for a test method. This determined lower limit represents the numerical limit at or above which the test results are considered to be quantitatively meaningful for commerce or regulatory activities by this practice. It is defined by this standard as the pooled limit of quantitation (PLOQ) for the test method.

1.2 This practice is applicable to test methods that are capable of producing numerical test results close to zero. Examples are those test methods that determine quantitatively the concentration of analyte(s) near zero.

1.3 This international standard was developed in accordance with internationally recognized principles on standardization established in the Decision on Principles for the Development of International Standards, Guides and Recommendations issued by the World Trade Organization Technical Barriers to Trade (TBT) Committee.

Document History

ASTM D6259-15(2019)
May 1, 2019
Standard Practice for Determination of a Pooled Limit of Quantitation for a Test Method
5.1 Background—In a single laboratory, the limit of quantitation, LOQ, equal to ten times the standard deviation obtained under repeatability conditions extrapolated to zero concentration (s0) based...
July 1, 2015
Standard Practice for Determination of a Pooled Limit of Quantitation for a Test Method
5.1 Background—In a single laboratory, the limit of quantitation, LOQ, equal to ten times the standard deviation obtained under repeatability conditions extrapolated to zero concentration (s0) based...
July 1, 2010
Standard Practice for Determination of a Pooled Limit of Quantitation
In a single laboratory, the limit of quantitation, LOQ, equal to ten standard deviations has been recommended.4 A test result at this LOQ has an uncertainty of ±30 % at the 99 % confidence level....
May 1, 2004
Standard Practice for Determination of a Pooled Limit of Quantitation
In a single laboratory, the limit of quantitation, LOQ, equal to ten standard deviations has been recommended.4 A test result at this LOQ has an uncertainty of ±30 % at the 99 % confidence level....
April 10, 1998
Standard Practice for Determination of a Pooled Limit of Quantitation
1.1 This practice covers the determination of a lower quantitative limit for a test method for the analyte. The determined lower limit is herinafter referred to as the pooled limit of quantitation....
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