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2006 Edition,
August 1, 2006
- IEEE - Institute of Electrical and Electronics Engineers, Inc.
In this work, parametric information-theory measures for the characterizationofbindingsites in DNA are extended with the use oftransitional probabilities on the sequence. We propose the use of parametric uncertainty...
2008 Edition,
Volume 7,
June 1, 2008
- IEEE - Institute of Electrical and Electronics Engineers, Inc.
In this work, parametric information-theory measures for the characterizationofbindingsites in DNA are extended with the use oftransitional probabilities on the sequence. We propose the use of parametric uncertainty...
2018 Edition,
December 1, 2018
- IEEE - Institute of Electrical and Electronics Engineers, Inc.
Discovering DNAbindingsites in genome sequences is crucial for understanding genomic regulation. Currently available computational tools for finding bindingsites with Position Weight Matrices of known motifs are often used in restricted genomic regions...
Volume PP
- IEEE - Institute of Electrical and Electronics Engineers, Inc.
A transcription factor (TF) is a protein that regulates gene expression bybinding to specific DNA sequences. Despite the recent advances in experimental techniques for identifying transcription factor bindingsites (TFBS) in DNA sequences, a large number...
Volume PP
- IEEE - Institute of Electrical and Electronics Engineers, Inc.
Through sequence-based classification, this paper tries to accurately predict the DNAbindingsitesof transcription factors (TFs) in an unannotated cellular context. Related methods in the literature fail to perform such predictions accurately, since they do not...
Volume PP
- IEEE - Institute of Electrical and Electronics Engineers, Inc.
Although Deep learning algorithms have outperformed conventional methods in predicting the sequence specificities ofDNA-protein binding, they lack to consider the dependencies among nucleotides and the diverse binding lengths for different transcription factors...
2018 Edition,
Volume 15,
September 1, 2018
- IEEE - Institute of Electrical and Electronics Engineers, Inc.
A transcription factor (TF) is a protein that regulates gene expression bybinding to specific DNA sequences. Despite recent advances in experimental techniques for identifying transcription factor bindingsites (TFBS) in DNA sequences, a large number...
Volume PP
- IEEE - Institute of Electrical and Electronics Engineers, Inc.
Accurately identifying DNA-binding proteins (DBPs) from protein sequence information is an important but challenging task for protein function annotations. In this paper, we establish a novel computational method, named TargetDBP, for accurately targeting DBPs from primary sequences....
2016 Edition,
December 1, 2016
- IEEE - Institute of Electrical and Electronics Engineers, Inc.
Transcription factors (TFs) are macromolecules that bind to cis-regulatory specific sub-regions ofDNA promoters and initiate transcription. Finding the exact location of these bindingsites (aka motifs) is important in a variety of domains such as drug...
Volume PP
- IEEE - Institute of Electrical and Electronics Engineers, Inc.
Knowing the transcription factor bindingsites (TFBSs) is essential for modeling the underlying binding mechanisms and follow-up cellular functions. Convolutional neural networks (CNNs) have outperformed methods in predicting TFBSs from the primary DNA sequence. In...
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