IEEE - Institute of Electrical and Electronics Engineers, Inc. - Reduced base-base interactions between the DNA seed and RNA target are the major determinants of a significant reduction in the off-target effect due to DNA-seed-containing siRNA

2009 International Symposium on Micro-NanoMechatronics and Human Science (MHS)

Author(s): Ui-Tei, K. ; Nishi, K. ; Naito, Y. ; Zenno, S. ; Juni, A. ; Saigo, K.
Publisher: IEEE - Institute of Electrical and Electronics Engineers, Inc.
Publication Date: 1 November 2009
Conference Location: Nagoya, Japan, Japan
Conference Date: 9 November 2009
Page(s): 298 - 304
ISBN (CD): 978-1-4244-5095-4
ISBN (Paper): 978-1-4244-5094-7
DOI: 10.1109/MHS.2009.5351913
Regular:

Previously, we showed that DNA replacement of the seed-containing region of class I siRNAs significantly reduced the off-target effect without substantial loss of target gene silencing activity... View More

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