The study nucleoti de substitution is very important both to our understanding of gene evolution and to reliable estimation of phylogenetic relationships. In this paper nucleotide substitution is assumed to be random and the Markov model is applied to the study of the evolution of genes. Then a non-...

The S100 family is a class of calcium-regulated proteins with EF-hand. They are widely distributed and are implicated in diverse intracellular and extracellular physiological processes. A study of the S100 family using computational biology methods such as multiple sequence alignment, structural ali...

The concept of Cooperative Work Environment (CWE) is introduced. Three key elements of CWE, inforrration integration, process integration, and organization integration, are analysed. An application framework of CWE is prcoosed and with this framework a CE CWE based on Lotus Notes/Domino and Intel Pr...

A novel multi-view 3D face registration method based on principal axis analysis and labeled regions orientation called local orientation registration is proposed. The pre-registration is achieved by transforming the multi-pose models to the standard frontal model's reference frame using the principa...

The epitope ELDKWA, which is located in the membrane-proximal external region (MPER) of HIV-1 gp41, is an important neutralizing epitope. The human monoclonal antibody (mAb) 2F5 against this epitope shows broad neutralizing activity toward many HIV strains. However, several reports have shown that t...